Description

(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(1H-Indol-4-Yl)Propanoic Acid CAS NO 1251904-20-7 is a high-purity, non-natural amino acid derivative featuring an indole side chain protected by the Fmoc (9-fluorenylmethoxycarbonyl) group. This compound is a critical building block for the solid-phase peptide synthesis (SPPS) of peptides and peptidomimetics, enabling the precise introduction of tryptophan analogs with modified indole ring positions. It is essential for researchers and manufacturers in pharmaceutical R&D and biotechnology who require advanced intermediates for developing novel therapeutic agents, diagnostic probes, and bioactive peptides.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Pharmaceutical Research & Development: Used as a building block in the discovery and development of novel drug candidates, particularly for oncology, neurology, and metabolic diseases.
• Peptidomimetic Design: Enables the creation of peptide analogs with enhanced stability, bioavailability, and target specificity by incorporating a modified indole moiety.
• Bioconjugation and Probe Development: Facilitates the site-specific labeling of peptides with fluorophores or other tags for diagnostic and imaging applications.
• Academic Research: Employed in biochemical and biophysical studies to investigate protein-protein interactions and enzyme mechanisms.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse libraries of compounds for high-throughput screening.

Basic Information

Product Name	(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(1H-Indol-4-Yl)Propanoic Acid
CAS No.	1251904-20-7
Molecular Formula	C26H22N2O4
Molecular Weight	426.47 g/mol
Synonyms	Fmoc-4-indolylalanine-OH; Fmoc-4-Ind-Ala-OH; Fmoc-(S)-2-amino-3-(1H-indol-4-yl)propanoic acid; (S)-2-(Fmoc-amino)-3-(1H-indol-4-yl)propanoic acid; Fmoc-4-Ial-OH; 4-Indolylalanine Fmoc derivative; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-indolyl-L-alanine; Nα-Fmoc-4-indolyl-L-alanine
EINECS	Contact for details

Quality Control

Our (S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(1H-Indol-4-Yl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical and chiral purity suitable for demanding peptide synthesis applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.