Description

2-Trifluoromethyl-1,8-Diaza-Spiro[4.5]Decane-8-Carboxylic Acid tert-Butyl Ester is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and diaza scaffold with a trifluoromethyl group. This compound is critical for medicinal chemistry research and development, offering a versatile building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in drug discovery programs targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, particularly those requiring spirocyclic architectures for enhanced metabolic stability and binding affinity.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing focused libraries and exploring structure-activity relationships (SAR) in early-stage drug discovery.
• Protease Inhibitor Development: The diaza-spiro structure is valuable in the design and development of novel protease enzyme inhibitors.
• Ligand Synthesis for Drug Discovery: Employed in the creation of sophisticated ligands for various biological targets, leveraging the trifluoromethyl group for modulating lipophilicity and electronic properties.
• Building Block for CNS-Active Compounds: The structural motif is relevant for developing compounds intended to cross the blood-brain barrier for neurological applications.
• Chemical Biology Probes: Utilized in the synthesis of chemical probes for studying biological pathways and target validation.

Basic Information

Product Name	2-Trifluoromethyl-1,8-Diaza-Spiro[4.5]Decane-8-Carboxylic Acid tert-Butyl Ester
CAS No.	1251020-85-5
Molecular Formula	C14H23F3N2O2
Molecular Weight	308.34 g/mol
Synonyms	tert-Butyl 2-(trifluoromethyl)-1,8-diazaspiro[4.5]decane-8-carboxylate; 1,8-Diaza-spiro[4.5]decane-8-carboxylic acid, 2-(trifluoromethyl)-, 1,1-dimethylethyl ester; 2-(Trifluoromethyl)-1,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; 8-Boc-2-trifluoromethyl-1,8-diazaspiro[4.5]decane; 2-Trifluoromethyl-1,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethyl-1,8-Diaza-Spiro[4.5]Decane-8-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.