Description

1-Bromo-4,5,7,8-Tetrahydro-2,3A,6-Triaza-Azulene-6-Carboxylic Acid tert-Butyl Ester (Wx140810) is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, particularly in areas requiring sophisticated nitrogen-containing scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug molecules, especially those with azulene or triaza-azulene core structures.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the discovery of new chemical entities in academic and industrial R&D labs.
• API Synthesis: Used in the production route for potential active pharmaceutical ingredients targeting central nervous system (CNS) disorders, inflammation, or oncology.
• Chemical Biology Probes: Employed in the development of specialized probes and tools for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity brominated heterocycles.

Basic Information

Item	Details
Product Name	1-Bromo-4,5,7,8-Tetrahydro-2,3A,6-Triaza-Azulene-6-Carboxylic Acid tert-Butyl Ester (Wx140810)
CAS No.	1251019-27-8
Molecular Formula	C14H18BrN3O2
Molecular Weight	340.22 g/mol
Synonyms	tert-Butyl 1-bromo-4,5,7,8-tetrahydro-2,3a,6-triazaazulene-6-carboxylate; 1-Bromo-4,5,7,8-tetrahydro-2,3a,6-triazaazulene-6-carboxylic acid 1,1-dimethylethyl ester; WX-140810; Wx140810; BOC-protected bromo-triaza-azulene; 6-(tert-Butoxycarbonyl)-1-bromo-4,5,7,8-tetrahydro-2,3a,6-triazaazulene
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-4,5,7,8-Tetrahydro-2,3A,6-Triaza-Azulene-6-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity consistent with cGMP guidelines for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and full analytical data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.