Description

trans-1,3,3A,4,5,9B-Hexahydro-Pyrrolo[3,4-C]Quinoline-2-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex, fused heterocyclic structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) agents and other therapeutic small molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing complex molecular libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Organic Synthesis: Serves as a protected precursor for the synthesis of more complex pyrroloquinoline derivatives and other nitrogen-containing heterocycles.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects and scale-up activities.
• Academic Research: Utilized in university and institutional labs for methodological development and the study of novel chemical transformations.

Basic Information

Product Name	trans-1,3,3A,4,5,9B-Hexahydro-Pyrrolo[3,4-C]Quinoline-2-Carboxylic Acid tert-Butyl Ester
CAS No.	1251017-31-8
Molecular Formula	C16H22N2O2
Molecular Weight	274.36 g/mol
Synonyms	tert-Butyl trans-1,3,3a,4,5,9b-hexahydro-2H-pyrrolo[3,4-c]quinoline-2-carboxylate; (3aR,9bS)-1,3,3a,4,5,9b-Hexahydro-2H-pyrrolo[3,4-c]quinoline-2-carboxylic acid 1,1-dimethylethyl ester; trans-1,3,3a,4,5,9b-Hexahydro-2H-pyrrolo[3,4-c]quinoline-2-carboxylic acid tert-butyl ester; BOC-protected pyrroloquinoline; tert-Butyl pyrrolo[3,4-c]quinoline-2-carboxylate derivative
EINECS	Contact for details

Quality Control

Our trans-1,3,3A,4,5,9B-Hexahydro-Pyrrolo[3,4-C]Quinoline-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity, NMR, and MS for structural confirmation, to ensure compliance with research and development grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.