Description

Spiro[Benzofuran-3(2H),4'-Piperidine]-1'-Carboxylic Acid, 5-Bromo-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and heterocyclic architecture. This compound is of significant commercial value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by R&D chemists and process development scientists in the global pharmaceutical and biotechnology sectors for constructing sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of new drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its spirocyclic benzofuran-piperidine core.
• Process Chemistry & Scale-up: Serves as a defined starting material or intermediate for kilogram-scale GMP manufacturing under controlled conditions.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and early-stage API development.
• Academic Research: Utilized in university and institutional labs for exploring new synthetic methodologies and heterocyclic chemistry.
• Library Synthesis: Employed for generating focused compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Item	Detail
Product Name	Spiro[Benzofuran-3(2H),4'-Piperidine]-1'-Carboxylic Acid, 5-Bromo-, 1,1-Dimethylethyl Ester
CAS No.	1251015-16-3
Molecular Formula	C18H22BrNO3
Molecular Weight	380.28 g/mol
Synonyms	5-Bromo-spiro[benzofuran-3(2H),4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 5-bromo-2,3-dihydrospiro[benzofuran-3,4'-piperidine]-1'-carboxylate; 5-Bromo-1'-Boc-spiro[benzofuran-3(2H),4'-piperidine]; 1'-Boc-5-bromospiro[benzofuran-3(2H),4'-piperidine]; 5-Bromo-spiro[2H-benzofuran-3,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester; 5-Bromo-1'-N-Boc-spiro[benzofuran-3,4'-piperidine]; 5-Bromo-1'-tert-butoxycarbonylspiro[benzofuran-3(2H),4'-piperidine]
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development under GMP-like conditions for projects requiring regulatory filing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.