Description

9-Oxo-1-Oxa-4-Aza-Spiro[5.5]Undecane-4-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic scaffold. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those targeting the central nervous system (CNS) and other specialized therapeutic areas.
• Protease Inhibitor Research: Serves as a core structural component in the development of novel protease inhibitors due to its spirocyclic lactam motif.
• Medicinal Chemistry & Drug Discovery: Used as a versatile scaffold for constructing diverse compound libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for potential API manufacturing.
• Chemical Biology Probes: Utilized in the design and synthesis of specialized molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	9-Oxo-1-Oxa-4-Aza-Spiro[5.5]Undecane-4-Carboxylic Acid tert-Butyl Ester
CAS No.	1251012-92-6
Molecular Formula	C13H21NO4
Molecular Weight	255.31 g/mol
Synonyms	tert-Butyl 9-oxo-1-oxa-4-azaspiro[5.5]undecane-4-carboxylate; 4-(tert-Butoxycarbonyl)-1-oxa-4-azaspiro[5.5]undecan-9-one; 1-Oxa-4-azaspiro[5.5]undecane-4-carboxylic acid, 9-oxo-, 1,1-dimethylethyl ester; 4-Boc-1-oxa-4-azaspiro[5.5]undecan-9-one; Boc-Protected Spirocyclic Lactam Intermediate
EINECS	Contact for details

Quality Control

Our 9-Oxo-1-Oxa-4-Aza-Spiro[5.5]Undecane-4-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.