Description

tert-Butyl 1-Benzyloxycarbonylamino-5-Aza-Spiro[2.3]Hexane-5-Carboxylate is a sophisticated, high-purity organic building block featuring a unique spirocyclic and protected amine architecture. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel, complex molecular scaffolds. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new active pharmaceutical ingredients (APIs) and bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space due to its constrained spirocyclic structure.
• Peptidomimetic Synthesis: The protected amino and carboxylate groups make it a valuable precursor for constructing non-natural amino acids and peptide analogs.
• Library Synthesis for High-Throughput Screening: Employed in the generation of diverse compound libraries for biological screening against various therapeutic targets.
• Process Chemistry Development: Used in scaling up synthetic routes for potential APIs during late-stage R&D and process optimization.
• Academic Research: A valuable reagent for universities and research institutes studying synthetic methodology, heterocyclic chemistry, and new reaction pathways.

Basic Information

Product Name	tert-Butyl 1-Benzyloxycarbonylamino-5-Aza-Spiro[2.3]Hexane-5-Carboxylate
CAS No.	1251012-85-7
Molecular Formula	C18H24N2O4
Molecular Weight	332.40 g/mol
Synonyms	5-Aza-spiro[2.3]hexane-5-carboxylic acid, 1-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester; 1-N-Cbz-5-N-Boc-5-azaspiro[2.3]hexane; tert-Butyl 1-((benzyloxy)carbonylamino)-5-azaspiro[2.3]hexane-5-carboxylate; 5-Azaspiro[2.3]hexane-1-carboxylic acid, N-[(benzyloxy)carbonyl]-, 1,1-dimethylethyl ester; Boc-5-Aza-spiro[2.3]hexane-1-N-Cbz; 1-Cbz-amino-5-Boc-5-azaspiro[2.3]hexane; 1251012-85-7
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-Benzyloxycarbonylamino-5-Aza-Spiro[2.3]Hexane-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and chiral analysis to ensure stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry best practices for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.