Description

5-Boc-5-Aza-Spiro[2.3]Hexane-1-Carboxylic Acid is a high-value, protected amino acid derivative featuring a unique spirocyclic structure, making it a critical building block in modern organic synthesis. This compound is essential for medicinal chemistry research and development, particularly in the construction of novel, conformationally constrained scaffolds for drug discovery. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers specializing in the synthesis of complex active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Peptidomimetics & Constrained Peptides: Used to introduce rigid, spirocyclic motifs into peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity.
• PROTAC (Proteolysis Targeting Chimera) Linker Chemistry: Serves as a structurally diverse component for constructing the linker region in bifunctional degrader molecules.
• Chemical Biology Probes: Employed in the development of tool compounds and molecular probes for studying enzyme function and protein-protein interactions.
• Agrochemical Research: Acts as an advanced intermediate in the discovery of new pesticides and herbicides with novel modes of action.
• Academic Research: Used in universities and research institutes for methodological development in asymmetric synthesis and heterocyclic chemistry.

Basic Information

Product Name	5-Boc-5-Aza-Spiro[2.3]Hexane-1-Carboxylic Acid
CAS No.	1251012-82-4
Molecular Formula	C11H17NO4
Molecular Weight	227.26 g/mol
Synonyms	1-[(1,1-Dimethylethoxy)carbonyl]-5-azaspiro[2.3]hexane-5-carboxylic Acid; 5-[(tert-Butoxycarbonyl)-5-azaspiro[2.3]hexane-1-carboxylic Acid; 5-Azaspiro[2.3]hexane-1-carboxylic acid, 5-(1,1-dimethylethyl) ester; 5-Boc-5-azaspiro[2.3]hexane-1-carboxylic acid; tert-Butyl 1-carboxy-5-azaspiro[2.3]hexane-5-carboxylate; Boc-5-Aza-Spiro[2.3]Hexane-1-COOH
EINECS	Contact for details

Quality Control

Our 5-Boc-5-Aza-Spiro[2.3]Hexane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We adhere to cGMP principles for advanced intermediates to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.