Description

tert-Butyl 8-Oxa-2,11-Diazaspiro-[5.6]Dodecane-11-Carboxylate CAS NO 1251010-92-0 is a high-value, advanced pharmaceutical intermediate belonging to the spirocyclic amine class. This compound serves as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with precise three-dimensional structures. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas such as central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting specific biological pathways.
• Drug Discovery & Medicinal Chemistry: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Spirocyclic Scaffold Synthesis: Provides the rigid, three-dimensional spirocyclic core essential for creating molecules with improved metabolic stability and receptor selectivity.
• Chemical Biology Research: Employed as a tool compound or building block for probing protein function and biological mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.
• Library Synthesis: Used to generate diverse compound libraries for high-throughput screening in early-stage drug discovery.

Basic Information

Product Name	tert-Butyl 8-Oxa-2,11-Diazaspiro-[5.6]Dodecane-11-Carboxylate
CAS No.	1251010-92-0
Molecular Formula	C13H24N2O3
Molecular Weight	256.34 g/mol
Synonyms	11-Boc-8-oxa-2,11-diazaspiro[5.6]dodecane; tert-Butyl 8-oxa-2,11-diazaspiro[5.6]dodecane-11-carboxylate; 8-Oxa-2,11-diazaspiro[5.6]dodecane-11-carboxylic acid, 1,1-dimethylethyl ester; 2,11-Diazaspiro[5.6]dodecane-11-carboxylic acid, 8-oxa-, 1,1-dimethylethyl ester; Boc-8-oxa-2,11-diazaspiro[5.6]dodecane; Spirocyclic amine Boc-protected intermediate
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Oxa-2,11-Diazaspiro-[5.6]Dodecane-11-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development and commercial projects with material suitable for research use and can provide grades aligned with cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Recommended storage temperature is 2-8°C for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.