Description

7-Oxa-2-Aza-Spiro[3.5]Nonane-2,5-Dicarboxylic Acid 2-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules with potential therapeutic activity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and optimization of API manufacturing routes.
• Proteolysis Targeting Chimera (PROTAC) Development: The spirocyclic structure can be incorporated into linkers or warheads for the design of targeted protein degraders.
• Chemical Biology Probes: Utilized in the creation of specialized molecular tools for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	7-Oxa-2-Aza-Spiro[3.5]Nonane-2,5-Dicarboxylic Acid 2-tert-Butyl Ester
CAS No.	1251009-59-2
Molecular Formula	C13H21NO5
Molecular Weight	271.31 g/mol
Synonyms	2-(tert-Butyl) 5-ethyl 7-oxa-2-azaspiro[3.5]nonane-2,5-dicarboxylate; 2-tert-Butyl 7-oxa-2-azaspiro[3.5]nonane-2,5-dicarboxylate; 7-Oxa-2-azaspiro[3.5]nonane-2,5-dicarboxylic acid, 2-(1,1-dimethylethyl) ester; Spiro[3.5]nonane-2,5-dicarboxylic acid derivative; 2-Azaspiro[3.5]nonane intermediate; OAN ester; tert-Butyl 2,5-dicarboxylate spirocyclic ether
EINECS	Contact for details

Quality Control

Every batch of 7-Oxa-2-Aza-Spiro[3.5]Nonane-2,5-Dicarboxylic Acid 2-tert-Butyl Ester is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is stable under these conditions but should be kept away from strong acids and organic solvents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.