Description

2-(tert-Butoxycarbonyl)-5-Oxa-2-Azaspiro[3.4]Octane-7-Carboxylic Acid is a high-value, protected spirocyclic amino acid derivative, serving as a critical building block in modern organic synthesis. Its core value lies in providing a rigid, functionalized scaffold that is essential for constructing complex molecular architectures with precise stereochemistry. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, particularly in the synthesis of novel drug candidates and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational rigidity into peptide backbones, enhancing metabolic stability and biological activity.
• Chemical Biology Probes: Employed in the development of activity-based probes and molecular tools for studying enzyme function and protein-protein interactions.
• Agrochemical Research: Serves as a building block for novel herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science: Potential monomer for creating specialty polymers with unique thermal and mechanical properties.
• Academic & Contract Research: Utilized in methodological development and the exploration of new synthetic routes in organic chemistry laboratories worldwide.

Basic Information

Item	Detail
Product Name	2-(tert-Butoxycarbonyl)-5-Oxa-2-Azaspiro[3.4]Octane-7-Carboxylic Acid
CAS No.	1251009-46-7
Molecular Formula	C12H19NO5
Molecular Weight	257.28 g/mol
Synonyms	Boc-5-Oxa-2-Azaspiro[3.4]octane-7-carboxylic Acid; 7-Carboxy-2-[(2-methylpropan-2-yl)oxycarbonyl]-5-oxa-2-azaspiro[3.4]octane; (7S)-2-[(tert-Butoxy)carbonyl]-5-oxa-2-azaspiro[3.4]octane-7-carboxylic Acid (for specific enantiomer); tert-Butyl 7-carboxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate; Boc-Spirocyclic Amino Acid Derivative; 5-Oxa-2-azaspiro[3.4]octane-7-carboxylic acid, 2-[(1,1-dimethylethoxy)carbonyl]-; Fmoc/Boc-Protected Spirocyclic Scaffold.
EINECS	Contact for details

Quality Control

Our 2-(tert-Butoxycarbonyl)-5-Oxa-2-Azaspiro[3.4]Octane-7-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under dry, inert conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (if applicable)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.