Description

tert-Butyl 8-oxo-2,7-diazaspiro[4.4]nonane-2-carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the diazaspirocyclic chemical class. This compound is a critical building block in modern medicinal chemistry, valued for its unique spirocyclic scaffold which is instrumental in modulating the physicochemical and pharmacokinetic properties of drug candidates. It is primarily utilized by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for clinical development.
• Protease Inhibitor Research: Used in the design and development of novel protease inhibitors for antiviral and anticancer therapies.
• Kinase Inhibitor Scaffold: Serves as a core structural element in the creation of potent and selective kinase inhibitors.
• Central Nervous System (CNS) Drug Discovery: Employed in medicinal chemistry programs aimed at developing drugs that cross the blood-brain barrier.
• Chemical Biology & Probe Development: Utilized as a versatile scaffold for creating chemical probes to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	tert-Butyl 8-oxo-2,7-diazaspiro[4.4]nonane-2-carboxylate
CAS No.	1251009-03-6
Molecular Formula	C12H20N2O3
Molecular Weight	240.30 g/mol
Synonyms	2,7-Diazaspiro[4.4]nonane-2-carboxylic acid, 8-oxo-, 1,1-dimethylethyl ester; 8-Oxo-2,7-diazaspiro[4.4]nonane-2-carboxylic acid tert-butyl ester; tert-Butyl 8-oxo-2,7-diazaspiro[4.4]nonane-2-carboxylate; 1251009-03-6; 2-tert-Butoxycarbonyl-8-oxo-2,7-diazaspiro[4.4]nonane; Boc-8-oxo-2,7-diazaspiro[4.4]nonane
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-oxo-2,7-diazaspiro[4.4]nonane-2-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications from early-stage research through to pre-clinical and cGMP-grade development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.