Description

1-Oxa-9-Aza-Spiro[5.5]Undecane-2,9-Dicarboxylic Acid 9-tert-Butyl Ester (Wx100285) is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is of significant commercial value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing novel molecular architectures with targeted biological activity.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry Development: Serves as a key starting material (KSM) or advanced intermediate in the scale-up and optimization of API manufacturing routes.
• Protease Inhibitor Synthesis: The spirocyclic structure is valuable for developing inhibitors of specific enzymes, such as proteases involved in viral replication.
• Ligand and Catalyst Development: Potential use in creating novel chiral ligands or organocatalysts for asymmetric synthesis.
• Academic Research: Employed in universities and research institutes for exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	1-Oxa-9-Aza-Spiro[5.5]Undecane-2,9-Dicarboxylic Acid 9-tert-Butyl Ester (Wx100285)
CAS No.	1251007-93-8
Molecular Formula	C14H23NO5
Molecular Weight	285.34 g/mol
Synonyms	9-tert-Butyl 1-Oxa-9-azaspiro[5.5]undecane-2,9-dicarboxylate; 9-(tert-Butoxycarbonyl)-1-oxa-9-azaspiro[5.5]undecane-2-carboxylic Acid; 1-Oxa-9-azaspiro[5.5]undecane-2,9-dicarboxylic Acid 9-(1,1-Dimethylethyl) Ester; WX-100285; Wx100285; BOC-Protected 1-Oxa-9-Azaspiro[5.5]Undecane-2-carboxylic Acid; Spirocyclic BOC-Amino Acid Ester
EINECS	Contact for details

Quality Control

Our 1-Oxa-9-Aza-Spiro[5.5]Undecane-2,9-Dicarboxylic Acid 9-tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D and process development. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under inert atmosphere (e.g., nitrogen) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.