Description

tert-Butyl 1',2'-Dihydrospiro[Azetidine-3,3'-Pyrrolo[3,2-B]Pyridine]-1-Carboxylate is a high-value, spirocyclic organic building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for constructing complex molecular architectures, particularly in the synthesis of novel drug candidates targeting central nervous system and oncological pathways. It is primarily utilized by medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries seeking to accelerate their discovery pipelines with reliable, high-purity intermediates.

Application

• Pharmaceutical Intermediate: A key scaffold in the research and synthesis of new chemical entities (NCEs) for drug discovery programs.
• Medicinal Chemistry: Used to explore structure-activity relationships (SAR) and to introduce the spiro[azetidine-pyrrolopyridine] core into potential bioactive molecules.
• API Development: Serves as a building block in the route development and scale-up of Active Pharmaceutical Ingredients (APIs), especially for neurological and oncological targets.
• Chemical Biology: Employed in the design and synthesis of chemical probes for studying biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and development projects.
• Academic Research: Used in university and institutional labs for methodological development in heterocyclic and spirocyclic chemistry.

Basic Information

Item	Details
Product Name	tert-Butyl 1',2'-Dihydrospiro[Azetidine-3,3'-Pyrrolo[3,2-B]Pyridine]-1-Carboxylate
CAS No.	1251005-78-3
Molecular Formula	C15H21N3O2
Molecular Weight	275.35 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-1',2'-dihydrospiro[azetidine-3,3'-pyrrolo[3,2-b]pyridine]; tert-Butyl 1,2-dihydrospiro[azetidine-3,3'-pyrrolo[3,2-b]pyridine]-1-carboxylate; Spiro[azetidine-3,3'-pyrrolo[3,2-b]pyridine]-1-carboxylic acid, 1,2-dihydro-, 1,1-dimethylethyl ester; 1251005-78-3; BOC-protected spirocyclic azetidine-pyrrolopyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl 1',2'-Dihydrospiro[Azetidine-3,3'-Pyrrolo[3,2-B]Pyridine]-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.