Description

tert-Butyl 5-(Hydroxymethyl)-3,4-Dihydro-2,7-Naphthyridine-2(1H)-Carboxylate (Wx140226) is a high-purity, advanced pharmaceutical intermediate with a CAS number of 1250999-83-7. This compound is a critical building block in modern medicinal chemistry, valued for its functionalized naphthyridine core which enables the synthesis of complex bioactive molecules. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug candidates targeting various disease pathways.
• Organic Synthesis Building Block: The tert-butyloxycarbonyl (Boc) protecting group and hydroxymethyl functionality make it a versatile reagent for constructing complex heterocyclic scaffolds.
• Contract Development & Manufacturing (CDMO): Supplied to CDMOs for cGMP-compliant production of clinical trial materials and commercial APIs.
• Academic & Industrial R&D: Employed in laboratories for developing new synthetic methodologies and exploring novel chemical entities.

Basic Information

Product Name	tert-Butyl 5-(Hydroxymethyl)-3,4-Dihydro-2,7-Naphthyridine-2(1H)-Carboxylate (Wx140226)
CAS No.	1250999-83-7
Molecular Formula	C14H20N2O3
Molecular Weight	264.32 g/mol
Synonyms	2,7-Naphthyridine-2(1H)-carboxylic acid, 5-(hydroxymethyl)-3,4-dihydro-, 1,1-dimethylethyl ester; tert-Butyl 5-(hydroxymethyl)-1,2,3,4-tetrahydro-2,7-naphthyridine-2-carboxylate; WX-140226; WX140226; 1-Boc-5-(hydroxymethyl)-1,2,3,4-tetrahydro-2,7-naphthyridine; 5-(Hydroxymethyl)-3,4-dihydro-2,7-naphthyridin-2(1H)-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-(Hydroxymethyl)-3,4-Dihydro-2,7-Naphthyridine-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.