Description

2-Amino-6,7-Dihydro-9H-Pyrimido[5,4-E][1,4]Diazepine-5,8-Dicarboxylic Acid Di-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a complex fused heterocyclic structure. This compound is critical for the synthesis of novel therapeutic agents, particularly in oncology and neurological research, where precise molecular architecture is paramount. It serves as a key building block for medicinal chemists and R&D teams in pharmaceutical, biotechnology, and fine chemical sectors developing next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of targeted kinase inhibitors and other biologically active molecules.
• Oncology Research: Used in the development of novel chemotherapeutic agents and targeted cancer therapies due to its privileged scaffold.
• Neurological Drug Discovery: Serves as a core structure for compounds targeting central nervous system (CNS) disorders.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) explorations to optimize potency and selectivity of lead compounds.
• Process Chemistry & Scale-Up: Used in route development and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Contract Research & Development (CRO/CMO): Supplied to research organizations and manufacturers specializing in custom synthesis and development services.

Basic Information

Product Name	2-Amino-6,7-Dihydro-9H-Pyrimido[5,4-E][1,4]Diazepine-5,8-Dicarboxylic Acid Di-tert-Butyl Ester
CAS No.	1250997-39-7
Molecular Formula	C18H26N4O4
Molecular Weight	362.43 g/mol
Synonyms	2-Amino-5,8-di-tert-butyl 6,7-dihydro-9H-pyrimido[5,4-e][1,4]diazepine-5,8-dicarboxylate; Di-tert-butyl 2-amino-6,7-dihydro-9H-pyrimido[5,4-e][1,4]diazepine-5,8-dicarboxylate; 2-Amino-6,7-dihydro-9H-pyrimido[5,4-e][1,4]diazepine-5,8-dicarboxylic acid bis(1,1-dimethylethyl) ester; CAS 1250997-39-7; Pyrimidodiazepine Derivative; tert-Butyl Ester Protected Intermediate
EINECS	Contact for details

Quality Control

Our 2-Amino-6,7-Dihydro-9H-Pyrimido[5,4-E][1,4]Diazepine-5,8-Dicarboxylic Acid Di-tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.