Description

6,6-Dioxo-6Lambda(6)-Thiaspiro[2.5]Octane-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic sulfone structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced metabolic stability and target specificity. It is primarily needed by research and development teams in the pharmaceutical and biotechnology sectors, particularly those focused on developing new small-molecule therapeutics for challenging disease targets.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and anti-inflammatory targets.
• Medicinal Chemistry Research: Used as a constrained scaffold to explore structure-activity relationships (SAR) and improve the pharmacokinetic properties of lead compounds.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker component due to its rigid, polar structure, connecting E3 ligase ligands to target protein binders.
• Chemical Biology Probes: Employed in the synthesis of tool compounds for studying enzyme function and protein-protein interactions within biological systems.
• Process Chemistry & Scale-up: Used in route scouting and optimization for the commercial-scale production of investigational new drugs.
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies involving spirocycles and sulfones.

Basic Information

Product Name	6,6-Dioxo-6Lambda(6)-Thiaspiro[2.5]Octane-1-Carboxylic Acid
CAS No.	1250754-10-9
Molecular Formula	C8H10O4S
Molecular Weight	202.23 g/mol
Synonyms	6λ6-Thiaspiro[2.5]octane-1-carboxylic acid, 6,6-dioxide; 1-Carboxy-6,6-dioxo-6λ6-thiaspiro[2.5]octane; Spiro[cyclopropane-1,1'-thiolane]-1'-carboxylic acid 1',1'-dioxide; Thiaspiro[2.5]octane-1-carboxylic acid, 6,6-dioxide; Cyclopropanespiro-1'-thiolane-1'-carboxylic acid S,S-dioxide; (1'-Carboxy-6',6'-dioxido-6'λ6-thiaspiro[cyclopropane-1,1'-thiolan]-6'-yl) (CAS style name).
EINECS	Contact for details

Quality Control

Our 6,6-Dioxo-6Lambda(6)-Thiaspiro[2.5]Octane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and full analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.