Description

Ethyl 4-Amino-1,1-dioxothiane-4-carboxylate is a high-purity, specialized organic building block featuring a unique sulfone and amino ester functionalized thiane ring system. This compound is valued for its role as a key chiral intermediate in the synthesis of complex pharmaceutical molecules, particularly in the development of novel therapeutics. It is primarily sought by research institutions and pharmaceutical companies engaged in medicinal chemistry, process R&D, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, particularly in therapeutic areas requiring complex heterocyclic scaffolds.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a key starting material or advanced intermediate in the scale-up and route scouting for API manufacturing.
• Sulfone Chemistry: Utilized in organic synthesis to exploit the properties of the sulfone group for further functionalization and coupling reactions.
• Asymmetric Synthesis: The chiral center provides a handle for the construction of enantiomerically pure compounds for biological testing.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for clients.

Basic Information

Product Name	Ethyl 4-Amino-1,1-dioxothiane-4-carboxylate
CAS No.	1250287-78-5
Molecular Formula	C8H15NO4S
Molecular Weight	221.27 g/mol
Synonyms	4-Amino-1,1-dioxo-1λ⁶-thiane-4-carboxylic acid ethyl ester; Ethyl 4-aminotetrahydro-2H-thiopyran-4-carboxylate 1,1-dioxide; 4-Amino-tetrahydro-2H-thiopyran-4-carboxylic acid ethyl ester S,S-dioxide; 1,1-Dioxo-1λ⁶-thiane-4-carboxylic acid, 4-amino-, ethyl ester; 4-(Ethoxycarbonyl)-1,1-dioxothian-4-amine
EINECS	Contact for details

Quality Control

Our Ethyl 4-Amino-1,1-dioxothiane-4-carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure identity, strength, quality, and purity. Certificates of Analysis (COA) documenting all release specifications are provided and available upon request. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.