Description

1-(Methylsulfonyl)Cyclobutanecarbonitrile is a high-value, functionalized cyclobutane derivative featuring both a sulfonyl and a nitrile group, making it a versatile and reactive synthon for advanced chemical synthesis. Its unique structure is critical for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This intermediate is essential for research and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce cyclobutane rings with specific functional handles.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, especially for introducing the constrained cyclobutane scaffold which can improve metabolic stability and potency.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the sulfonyl and nitrile functionalities contribute to biological activity.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the development of specialized polymers with unique thermal or mechanical properties.
• Ligand and Catalyst Development: Employed in organic and organometallic chemistry to create novel ligands for catalysis or metal-organic frameworks (MOFs).
• Chemical Biology Probe Synthesis: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, multi-step organic transformations.

Basic Information

Item	Detail
Product Name	1-(Methylsulfonyl)Cyclobutanecarbonitrile
CAS No.	1248918-52-6
Molecular Formula	C6H9NO2S
Molecular Weight	159.21 g/mol
Synonyms	Cyclobutanecarbonitrile, 1-(methylsulfonyl)-; 1-(Methanesulfonyl)cyclobutanecarbonitrile; (1-Cyanocyclobutyl)(methyl)sulfone; Methylsulfonyl Cyclobutanecarbonitrile; 1-Methylsulfonylcyclobutanecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of 1-(Methylsulfonyl)Cyclobutanecarbonitrile is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from advanced techniques such as HPLC, GC, NMR, and mass spectrometry. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.