Description

Endo-tert-Butyl 8-Hydroxy-3-Azabicyclo[3.2.1]Octane-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex, rigid bicyclic scaffold. This compound is critical for research and development in medicinal chemistry, serving as a key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and antiviral drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly those targeting neurological pathways.
• Medicinal Chemistry Research: Used as a constrained scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• API Development: Serves as a critical precursor in the development and scale-up of new Active Pharmaceutical Ingredients (APIs) requiring the 3-azabicyclo[3.2.1]octane core structure.
• Asymmetric Synthesis: Employed in stereoselective synthesis due to its defined endo configuration, enabling the construction of molecules with high enantiomeric purity.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale production under current Good Manufacturing Practice (cGMP) guidelines where required.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and development services for the global pharmaceutical industry.

Basic Information

Product Name	Endo-tert-Butyl 8-Hydroxy-3-Azabicyclo[3.2.1]Octane-3-Carboxylate
CAS No.	1246947-33-0
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	endo-8-Hydroxy-3-azabicyclo[3.2.1]octane-3-carboxylic acid tert-butyl ester; tert-Butyl endo-8-hydroxy-3-azabicyclo[3.2.1]octane-3-carboxylate; (1R,5S)-8-Hydroxy-3-azabicyclo[3.2.1]octane-3-carboxylic acid tert-butyl ester; endo-BOC-8-Hydroxy-3-azabicyclooctane; 8-Hydroxy-3-aza-bicyclo[3.2.1]octane-3-carboxylic acid tert-butyl ester (endo); 3-Azabicyclo[3.2.1]octane-3-carboxylic acid, 8-hydroxy-, 1,1-dimethylethyl ester, (1R,5S)- BOC-8-Hydroxy-3-azanorbornane (endo)
EINECS	Contact for details

Quality Control

Our Endo-tert-Butyl 8-Hydroxy-3-Azabicyclo[3.2.1]Octane-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets exacting specifications for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (endo isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.