Description

11-Carboxyundecyl Methanethiosulfonate is a specialized, bifunctional chemical reagent featuring a terminal carboxylic acid group and a methanethiosulfonate (MTS) moiety. This compound is engineered for site-specific protein and peptide modification, enabling controlled bioconjugation and labeling strategies. It is a critical tool for researchers and manufacturers in biopharmaceutical development, proteomics, and diagnostic assay production, where precise molecular attachment is required.

Application

• Site-Directed Protein Labeling: The methanethiosulfonate group selectively reacts with cysteine thiols, allowing for the controlled introduction of fluorescent dyes, biotin, or other probes via the carboxylic acid handle.
• Bioconjugation and Crosslinking: Used to create stable thioether linkages between proteins, peptides, and other biomolecules or solid surfaces for assay and sensor development.
• Antibody-Drug Conjugate (ADC) Research: Serves as a heterobifunctional linker in the early-stage research and development of novel ADC constructs.
• Surface Functionalization: Immobilization of biomolecules onto carboxyl-reactive surfaces (e.g., NHS-activated chips, beads) for biosensor and microarray fabrication.
• Structural Biology Studies: Introduction of spectroscopic probes or spin labels at specific sites in proteins for analysis by techniques like FRET or EPR spectroscopy.
• Peptide Synthesis and Modification: A building block for introducing a cleavable or modifiable linker into synthetic peptides during solid-phase peptide synthesis (SPPS).

Basic Information

Product Name	11-Carboxyundecyl Methanethiosulfonate
CAS No.	1246819-91-9
Molecular Formula	C13H26O4S2
Molecular Weight	310.47 g/mol
Synonyms	11-(Methanethiosulfonyl)undecanoic acid; 11-Methanethiosulfonylundecanoic Acid; MTS-COOH (C11); Carboxy-PEG11-MTS; Undecane-11-carboxylic acid, 11-(methanesulfonothioate); Heterobifunctional MTS linker; Thiol-reactive carboxylic acid linker; C11-MTS-COOH
EINECS	Contact for details

Quality Control

Every batch of 11-Carboxyundecyl Methanethiosulfonate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and performance consistency. Our quality system is designed to meet the exacting standards of research and biopharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), identity confirmation (by NMR and MS), and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the container under an inert atmosphere (e.g., argon or nitrogen) at -20°C or below. The product is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.