Description

2-(1-{8-Azaspiro[Bicyclo[3.2.1]Octane-3,2'-Oxirane]-8-Yl}Ethyl)-2-Cyano-1,2-Dihydropyridine-4-Carboxylic Acid is a sophisticated, high-purity pharmaceutical intermediate featuring a unique spirocyclic and oxirane-fused molecular architecture. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular scaffolds. It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially those targeting the central nervous system (CNS) or other specialized receptors.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization due to its complex, three-dimensional structure.
• Process Chemistry Development: Serves as a standard or starting material for developing and scaling up robust, GMP-compliant synthetic routes for new APIs.
• Chemical Biology Probes: Utilized in the development of specialized molecular probes for studying biological pathways and target engagement.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies with custom synthesis and development services.
• Academic Research: Employed in university and institutional labs for advanced studies in synthetic organic chemistry and new methodology development.

Basic Information

Product Name	2-(1-{8-Azaspiro[Bicyclo[3.2.1]Octane-3,2'-Oxirane]-8-Yl}Ethyl)-2-Cyano-1,2-Dihydropyridine-4-Carboxylic Acid
CAS No.	1245647-05-5
Molecular Formula	C17H21N3O3
Molecular Weight	315.37 g/mol
Synonyms	2-Cyano-2-[1-(8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxirane]-8-yl)ethyl]-1,2-dihydropyridine-4-carboxylic acid; 2-(1-(8-Azaspiro[bicyclo[3.2.1]octane-3,2'-oxirane]-8-yl)ethyl)-2-cyano-1,4-dihydropyridine-4-carboxylic acid; CAS 1245647-05-5; 8-Azaspiro[bicyclo[3.2.1]octane-3,2'-oxirane] derivative; Spiro-oxirane pyridinecarboxylic acid intermediate.
EINECS	Contact for details

Quality Control

Our 2-(1-{8-Azaspiro[Bicyclo[3.2.1]Octane-3,2'-Oxirane]-8-Yl}Ethyl)-2-Cyano-1,2-Dihydropyridine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, to ensure it meets the high standards required for pharmaceutical R&D and development. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (on dried basis)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.