Description

4-Bromothiazole-5-Carboxylic Acid is a high-value brominated heterocyclic building block essential for advanced organic synthesis. This compound is prized for its reactive carboxylic acid and bromine functional groups, enabling precise molecular construction in complex chemical architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the design and production of advanced pesticides and herbicides, leveraging the thiazole core for biological activity.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules and probes for studying biological pathways and target engagement.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination.
• Peptidomimetics & Bioisosteres: The thiazole carboxylic acid moiety is used to create bioisosteric replacements in peptide-based drug design.

Basic Information

Product Name	4-Bromothiazole-5-Carboxylic Acid
CAS No.	1244949-48-1
Molecular Formula	C4H2BrNO2S
Molecular Weight	207.03 g/mol
Synonyms	5-Bromothiazole-4-carboxylic Acid; 4-Bromo-1,3-thiazole-5-carboxylic acid; Thiazole-5-carboxylic acid, 4-bromo-; 4-Bromothiazole-5-carboxylic acid; 4-Bromo-thiazole-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Bromothiazole-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and current industry standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat and incompatible materials. The product is light-sensitive and should be handled accordingly.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.