Description

3-Cyano-5-(Trifluoromethyl)Phenol, also known as 3-Cyano-5-Hydroxybenzotrifluoride, is a high-value, multi-functional aromatic intermediate featuring both a cyano and a trifluoromethyl group on the phenol ring. This unique molecular structure makes it a critical building block for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where electronic properties and metabolic stability are paramount. It is essential for R&D and production in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine and nitrile functionalities into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitors, anti-inflammatory agents, and CNS-active compounds where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the cyano and trifluoromethyl groups contribute to biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for constructing polar aromatic cores in electronic display materials, leveraging its electron-withdrawing groups to fine-tune molecular polarity and photophysical properties.
• Polymer & Resin Modifier: Incorporated into high-performance polymers to impart specific characteristics such as increased chemical resistance, thermal stability, or altered solubility.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, nucleophilic aromatic substitutions, and as a precursor for further functionalization to carboxylic acids, amides, or heterocycles.

Basic Information

Item	Details
Product Name	3-Cyano-5-(Trifluoromethyl)Phenol
CAS No.	1243459-56-4
Molecular Formula	C8H4F3NO
Molecular Weight	187.12 g/mol
Synonyms	3-Cyano-5-Hydroxybenzotrifluoride; 5-Hydroxy-3-(trifluoromethyl)benzonitrile; 3-Hydroxy-5-(trifluoromethyl)benzonitrile; 3-(Trifluoromethyl)-5-hydroxybenzonitrile; Phenol, 3-cyano-5-(trifluoromethyl)-; Benzotrifluoride, 3-cyano-5-hydroxy-
EINECS	Contact for details

Quality Control

Every batch of 3-Cyano-5-(Trifluoromethyl)Phenol is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards through rigorous analytical protocols including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.