Description

Ethyl(3Ar,4S,9Bs)-8-Acetyl-3A,4,5,9B-Tetrahydro-3H-Cyclopenta[C]Quinoline-4-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex, stereochemically defined cyclopentaquinoline structure. This compound is critical for the research and development of novel therapeutic agents, particularly in the fields of oncology and central nervous system (CNS) disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers requiring a reliable source of sophisticated chiral building blocks.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities (NCEs).
• Oncology Drug Development: Potential building block for small molecule inhibitors and targeted cancer therapies.
• CNS-Active Compound Synthesis: Employed in the development of compounds for neurological and psychiatric conditions.
• Asymmetric Synthesis: Utilized as a chiral template or reagent in stereoselective chemical transformations.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Used in university and institutional labs for exploratory synthetic chemistry and pharmacology projects.

Basic Information

Product Name	Ethyl(3Ar,4S,9Bs)-8-Acetyl-3A,4,5,9B-Tetrahydro-3H-Cyclopenta[C]Quinoline-4-Carboxylate
CAS No.	1243175-48-5
Molecular Formula	C19H21NO3
Molecular Weight	311.38 g/mol
Synonyms	Ethyl 8-acetyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylate; (3aR,4S,9bS)-Ethyl 8-acetyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylate; 8-Acetyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid ethyl ester; CAS 1243175-48-5; Cyclopenta[c]quinoline-4-carboxylate derivative; Chiral cyclopentaquinoline intermediate; Advanced pharmaceutical building block.
EINECS	Contact for details

Quality Control

Our Ethyl(3Ar,4S,9Bs)-8-Acetyl-3A,4,5,9B-Tetrahydro-3H-Cyclopenta[C]Quinoline-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and stereochemical purity suitable for demanding pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. Production can be aligned with cGMP guidelines for advanced project phases upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be light-sensitive and hygroscopic; therefore, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.