Description

Methyl 2-Chloro-6-Fluoroquinoline-4-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly within the quinolone and fluoroquinolone therapeutic classes. It is essential for research and development chemists, process scale-up engineers, and manufacturers in the global pharmaceutical and fine chemical industries seeking reliable, high-quality raw materials for complex synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of next-generation antibacterial and antimicrobial fluoroquinolone APIs.
• Chemical Research & Development: Used in medicinal chemistry for the design and discovery of new drug candidates with quinolone-based scaffolds.
• Process Chemistry & Scale-Up: Employed in the optimization and commercial-scale manufacturing of target molecules for clinical trials and production.
• Fine Chemical Synthesis: Serves as a versatile building block for creating complex, multi-functional heterocyclic compounds in custom synthesis projects.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	Methyl 2-Chloro-6-Fluoroquinoline-4-Carboxylate
CAS No.	1243032-25-8
Molecular Formula	C11H7ClFNO2
Molecular Weight	239.63 g/mol
Synonyms	Methyl 2-chloro-6-fluoro-4-quinolinecarboxylate; 2-Chloro-6-fluoroquinoline-4-carboxylic acid methyl ester; 4-Quinolinecarboxylic acid, 2-chloro-6-fluoro-, methyl ester; Methyl 2-chloro-6-fluoro-4-quinolinecarboxylate; 1243032-25-8; 2-Chloro-6-fluoro-4-quinolinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Chloro-6-Fluoroquinoline-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the highest standards of purity and consistency required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.