Description

4-Amino-8-Chloro-5-Methoxyquinoline-3-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This quinoline derivative is valued for its role as a critical building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, including potential antimicrobials and anticancer compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those with quinoline-based pharmacophores.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Antimicrobial Agent Development: Serves as a core scaffold for developing novel compounds with potential antibacterial or antifungal activity.
• Oncology Research: Investigated as a building block for potential kinase inhibitors and other targeted cancer therapies.
• Chemical Synthesis: Employed in organic synthesis for constructing more complex heterocyclic systems due to its reactive amino and ester functional groups.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	4-Amino-8-Chloro-5-Methoxyquinoline-3-Carboxylic Acid Ethyl Ester
CAS No.	1242260-35-0
Molecular Formula	C₁₃H₁₃ClN₂O₃
Molecular Weight	280.71 g/mol
Synonyms	Ethyl 4-Amino-8-chloro-5-methoxyquinoline-3-carboxylate; 8-Chloro-5-methoxy-4-aminoquinoline-3-carboxylic acid ethyl ester; 4-Amino-8-chloro-5-methoxy-3-quinolinecarboxylic acid ethyl ester; AQEE; 1242260-35-0; Quinoline-3-carboxylic acid, 4-amino-8-chloro-5-methoxy-, ethyl ester
EINECS	Contact for details

Quality Control

Our 4-Amino-8-Chloro-5-Methoxyquinoline-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.