Description

4-Amino-7,8-Difluoroquinoline-3-Carboxylic Acid Ethyl Ester is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in its unique difluoroquinoline scaffold, which is strategically designed to enhance the biological activity and metabolic stability of target molecules. This compound is critically needed by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas like anti-infectives and oncology.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel fluoroquinolone antibiotics and other drug candidates targeting bacterial DNA gyrase and topoisomerase IV.
• Agrochemical Research: Serves as a building block for developing new generation pesticides and herbicides, where the fluorine atoms improve lipophilicity and membrane penetration.
• Material Science: Used in the research and development of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology Probe Synthesis: Employed to create fluorescent tags or molecular probes for studying biological processes and enzyme interactions.
• Academic & Contract Research: A vital reagent for universities and CROs (Contract Research Organizations) conducting research in medicinal chemistry and heterocyclic compound synthesis.

Basic Information

Product Name	4-Amino-7,8-Difluoroquinoline-3-Carboxylic Acid Ethyl Ester
CAS No.	1242260-29-2
Molecular Formula	C₁₂H₁₀F₂N₂O₂
Molecular Weight	252.22 g/mol
Synonyms	Ethyl 4-Amino-7,8-difluoroquinoline-3-carboxylate; 7,8-Difluoro-4-aminoquinoline-3-carboxylic Acid Ethyl Ester; 4-Amino-7,8-difluoro-3-quinolinecarboxylic Acid Ethyl Ester; 1242260-29-2; 4-Amino-7,8-difluoroquinoline-3-carboxylate ethyl ester; AI3-63566
EINECS	Contact for details

Quality Control

Every batch of 4-Amino-7,8-Difluoroquinoline-3-Carboxylic Acid Ethyl Ester is manufactured and tested under a strict quality management system. We ensure compliance with high-purity standards suitable for research and pharmaceutical development. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) is provided with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.