Description

4-Bromo-5,8-Difluoroquinoline-3-Carboxylic Acid Ethyl Ester is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for researchers and manufacturers requiring precise molecular modifications to develop novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily utilized by pharmaceutical R&D teams, agrochemical innovators, and specialty chemical producers focused on creating next-generation fluorinated and brominated quinolone derivatives.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel fluorinated quinolone antibiotics and other bioactive molecules targeting bacterial infections.
• Agrochemical Research: Serves as a core scaffold for developing new fungicides and herbicides, leveraging the bioactivity of the difluoroquinoline structure.
• Material Science Precursor: Used in the development of organic electronic materials, such as OLEDs and semiconductors, where fluorinated and brominated heterocycles are essential.
• Chemical Biology Probe: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a labeling or cross-linking agent due to its reactive bromo and ester functionalities.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Item	Details
Product Name	4-Bromo-5,8-Difluoroquinoline-3-Carboxylic Acid Ethyl Ester
CAS No.	1242260-20-3
Molecular Formula	C₁₂H₈BrF₂NO₂
Molecular Weight	316.10 g/mol
Synonyms	Ethyl 4-Bromo-5,8-difluoroquinoline-3-carboxylate; 4-Bromo-5,8-difluoro-3-quinolinecarboxylic Acid Ethyl Ester; 1242260-20-3; 4-Bromo-5,8-difluorochinolin-3-carbonsäure-ethylester; Ethyl 4-bromo-5,8-difluoroquinoline-3-carboxylate; 5,8-Difluoro-4-bromoquinoline-3-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our 4-Bromo-5,8-Difluoroquinoline-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up processes. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical and agrochemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Maximum Impurity	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.