Description

4-Amino-5,7-Difluoroquinoline-3-Carboxylic Acid Ethyl Ester is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters as a critical intermediate for developing novel pharmaceuticals, particularly in the creation of kinase inhibitors and other targeted therapeutic agents. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce complex fluorinated quinoline scaffolds into their molecular designs.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially protein kinase inhibitors and anticancer agents.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides leveraging the fluorinated quinoline structure.
• Fluorescent Probe Development: Serves as a precursor for creating specialized fluorophores and sensing materials used in bioimaging and diagnostics.
• Material Science: Employed in the synthesis of organic electronic materials and advanced polymers requiring specific fluorinated aromatic components.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry and for building compound libraries in high-throughput screening.

Basic Information

Item	Details
Product Name	4-Amino-5,7-Difluoroquinoline-3-Carboxylic Acid Ethyl Ester
CAS No.	1242260-09-8
Molecular Formula	C₁₂H₁₀F₂N₂O₂
Molecular Weight	252.22 g/mol
Synonyms	Ethyl 4-Amino-5,7-difluoroquinoline-3-carboxylate; 4-Amino-5,7-difluoro-3-quinolinecarboxylic Acid Ethyl Ester; 5,7-Difluoro-4-aminoquinoline-3-carboxylic Acid Ethyl Ester; 1242260-09-8; 4-Amino-5,7-difluoroquinoline-3-carboxylic acid ethyl ester; Ethyl 4-amino-5,7-difluoroquinoline-3-carboxylate; AI3-63535; AKOS040759623; ZINC000257830716
EINECS	Contact for details

Quality Control

Our 4-Amino-5,7-Difluoroquinoline-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.