Description

4-Bromo-6-(Trifluoromethyl)Quinoline-3-Carboxylic Acid Ethyl Ester is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound matters because it combines a bromo-substituted quinoline core with a trifluoromethyl group, offering unique reactivity and physicochemical properties for creating novel molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery, material science, and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting kinases and other enzyme families.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the quinoline scaffold and the metabolic stability imparted by the trifluoromethyl group.
• Material Science: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient quinoline structure.
• Chemical Biology Probe Development: Utilized to create fluorescent probes or photoaffinity labels for studying biological processes and target engagement.
• Cross-Coupling Reactions: The bromine atom provides an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce diverse aryl or alkynyl groups.
• Ligand Synthesis: Can be functionalized to create novel chelating ligands for catalysis or metal-organic frameworks (MOFs).

Basic Information

Item	Details
Product Name	4-Bromo-6-(Trifluoromethyl)Quinoline-3-Carboxylic Acid Ethyl Ester
CAS No.	1242260-07-6
Molecular Formula	C₁₃H₉BrF₃NO₂
Molecular Weight	348.12 g/mol
Synonyms	Ethyl 4-Bromo-6-(trifluoromethyl)quinoline-3-carboxylate; 4-Bromo-6-trifluoromethylquinoline-3-carboxylic acid ethyl ester; 3-Quinolinecarboxylic acid, 4-bromo-6-(trifluoromethyl)-, ethyl ester; 1242260-07-6; Ethyl 4-bromo-6-(trifluoromethyl)-3-quinolinecarboxylate
EINECS	Contact for details

Quality Control

Our production of 4-Bromo-6-(Trifluoromethyl)Quinoline-3-Carboxylic Acid Ethyl Ester adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your critical research and development. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request and can be provided to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.