Description

(1S,2R,3S,4R)-3-(tert-Butoxycarbonylamino)Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid CAS NO 1242184-46-8 is a high-purity, stereochemically defined bicyclic amino acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in the rigid norbornene scaffold and protected amine functionality, which are essential for constructing complex molecular architectures with precise spatial orientation. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for applications in medicinal chemistry, including the development of protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Peptidomimetic Research: Used to introduce constrained, bicyclic structures into peptide backbones to enhance metabolic stability and receptor selectivity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Advanced Material Science: Potential monomer for creating specialty polymers with unique thermal and mechanical properties derived from the norbornene core.

Basic Information

Product Name	(1S,2R,3S,4R)-3-(tert-Butoxycarbonylamino)Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid
CAS No.	1242184-46-8
Molecular Formula	C₁₄H₂₁NO₄
Molecular Weight	267.32 g/mol
Synonyms	(1S,2R,3S,4R)-3-[(tert-Butoxycarbonyl)amino]bicyclo[2.2.1]hept-5-ene-2-carboxylic acid; (1S,2R,3S,4R)-3-(Boc-amino)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid; endo-(1S,2R,3S,4R)-3-(tert-Butoxycarbonylamino)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid; Boc-3-amino-2-norbornene-2-carboxylic acid (stereospecific); (1S,2R,3S,4R)-Boc-Amino-Norbornene-Carboxylic Acid; N-Boc-3-amino-2-norbornenecarboxylic acid (specific isomer); 1242184-46-8
EINECS	Contact for details

Quality Control

Our production of (1S,2R,3S,4R)-3-(tert-Butoxycarbonylamino)Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid adheres to stringent quality management protocols. Each batch is characterized and tested using advanced analytical techniques (including HPLC, NMR, and optical rotation) to ensure high chiral purity and chemical identity. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided to guarantee consistency and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.