Description

6-Aza-Spiro[2.5]Octane-1-Carboxylic Acid is a high-value, spirocyclic organic building block featuring a constrained bicyclic structure with a carboxylic acid functional group. This compound matters as a sophisticated intermediate for medicinal chemistry, enabling the exploration of novel three-dimensional chemical space in drug discovery programs. Pharmaceutical researchers and fine chemical manufacturers need it for the synthesis of potential therapeutic agents, particularly in developing new central nervous system (CNS) and metabolic disease treatments.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in fragment-based drug discovery and lead optimization to introduce conformational rigidity and improve pharmacokinetic properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead design for targeted protein degradation molecules.
• Chemical Biology Probes: Utilized in the creation of molecular probes to study enzyme function and biological pathways.
• Peptidomimetics: Incorporated into peptide analogs to enhance metabolic stability and receptor selectivity.
• Agrochemical Synthesis: Potential intermediate for developing advanced crop protection agents with novel modes of action.

Basic Information

Product Name	6-Aza-Spiro[2.5]Octane-1-Carboxylic Acid
CAS No.	1242028-68-7
Molecular Formula	C8H11NO2
Molecular Weight	153.18 g/mol
Synonyms	1-Carboxy-6-azaspiro[2.5]octane; 6-Azaspiro[2.5]octane-1-carboxylic acid; 1-Azaspiro[2.5]octane-6-carboxylic acid (tautomer); 1-Carboxy-1-azaspiro[2.5]octane; Spiro[cyclopropane-1,2'-piperidine]-6'-carboxylic acid; 6'-Carboxyspiro[cyclopropane-1,2'-piperidine]; Aza-spiro-octane carboxylic acid; 1242028-68-7
EINECS	Contact for details

Quality Control

Our 6-Aza-Spiro[2.5]Octane-1-Carboxylic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring GMP-grade intermediates and research materials for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is compatible with strong acid/organic solvent environments but should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.