Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-(4-Ethyl-1-Piperazinyl)-6-Fluoro-1,4-Dihydro-4-Oxo-, (3,5-Difluorophenyl)Methyl Ester is a sophisticated, high-purity pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly within the fluoroquinolone antibiotic class. Pharmaceutical R&D and manufacturing teams require this high-value intermediate to develop and produce next-generation antibacterial agents, where precise molecular architecture is paramount for efficacy and safety.

Application

• Pharmaceutical Intermediate: Primary use as a critical precursor in the synthesis of novel fluoroquinolone antibiotics.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key scaffold in medicinal chemistry for creating new antibacterial compounds with targeted activity.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for scale-up and GMP production of clinical trial materials and commercial APIs.
• Biochemical Research: Used in academic and industrial research to study structure-activity relationships (SAR) of quinolone derivatives.
• Process Chemistry: Employed in route scouting and optimization for efficient, scalable API synthesis.
• Reference Standard: High-purity grades are suitable for use as analytical standards in quality control laboratories.

Basic Information

Item	Detail
Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-(4-Ethyl-1-Piperazinyl)-6-Fluoro-1,4-Dihydro-4-Oxo-, (3,5-Difluorophenyl)Methyl Ester
CAS No.	1242006-37-6
Molecular Formula	C26H25F3N4O3
Molecular Weight	498.50 g/mol
Synonyms	1-Cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (3,5-difluorophenyl)methyl ester; (3,5-Difluorophenyl)methyl 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate; GSK2140944 Intermediate; GSK'044 Intermediate; Besifloxacin Related Compound; Advanced Fluoroquinolone Intermediate
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to meet stringent specifications for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and residual solvent content is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.