Description

5-Bromo-2,3-Difluoro-4-(Trimethylsilyl)Benzoic Acid is a high-value, multi-functional aromatic building block featuring a unique combination of halogen and silicon substituents. This compound is essential for advanced organic synthesis, particularly in the development of complex molecules where precise structural modification is required. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorine-containing drugs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides, where the bromine and fluorine atoms contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Acts as a building block for advanced electronic materials, where the trimethylsilyl and halogen groups help tune electronic properties and molecular alignment.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Protecting Group Strategy: The carboxylic acid functionality allows for derivatization, while the trimethylsilyl group can act as a protective moiety or be utilized in further silicon-based chemistry.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	5-Bromo-2,3-Difluoro-4-(Trimethylsilyl)Benzoic Acid
CAS No.	1241948-58-2
Molecular Formula	C10H11BrF2O2Si
Molecular Weight	309.18 g/mol
Synonyms	4-(Trimethylsilyl)-5-bromo-2,3-difluorobenzoic acid; 5-Bromo-2,3-difluoro-4-(trimethylsilyl)benzoic acid; Benzoic acid, 5-bromo-2,3-difluoro-4-(trimethylsilyl)-; 1241948-58-2; 5-Br-2,3-diF-4-TMS-benzoic acid
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2,3-Difluoro-4-(Trimethylsilyl)Benzoic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.