Description

3,5-Dichloro-D-Phenylalanine is a non-natural, chiral amino acid derivative characterized by its specific halogen substitution pattern. This compound matters as a high-value synthetic intermediate, offering a defined stereocenter and reactive handles for constructing complex molecules in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as peptide mimetics and active pharmaceutical ingredient (API) synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology and CNS research.
• Peptidomimetics: Used to incorporate halogenated phenylalanine analogs into peptide chains to modulate bioactivity, stability, and binding affinity.
• Chiral Auxiliary/Synthon: Serves as a source of chirality in asymmetric synthesis due to its D-configuration.
• Agrochemical Research: Intermediate in the development of new herbicides or plant growth regulators with specific activity profiles.
• Biochemical Tool: Potential use in enzyme inhibition studies or as a substrate analog in metabolic pathway research.
• Material Science: Monomer for specialized polymers or coatings requiring halogenated aromatic components.

Basic Information

Product Name	3,5-Dichloro-D-Phenylalanine
CAS No.	1241680-31-8
Molecular Formula	C9H9Cl2NO2
Molecular Weight	234.08 g/mol
Synonyms	D-3,5-Dichlorophenylalanine; (R)-2-Amino-3-(3,5-dichlorophenyl)propanoic acid; (R)-3,5-Dichloro-DL-phenylalanine; 3,5-Dichloro-D-Phe; 3,5-DiCl-D-Phe-OH; 3,5-Dichloro-(R)-phenylalanine; UNII-7V8A6U31JN; D-3,5-DiClPhe
EINECS	Contact for details

Quality Control

Our 3,5-Dichloro-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.