Description

(1R,4R)-2,5-Diazabicyclo[2.2.2]Octane-2-Carboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, chiral bicyclic diamine derivative that serves as a critical building block in advanced organic synthesis. Its rigid, three-dimensional structure and defined stereochemistry make it an invaluable scaffold for constructing complex molecules with precise spatial orientation. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), catalysts, and sophisticated ligands for asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and antiviral therapeutics.
• Asymmetric Catalyst Ligand: Used to construct privileged ligand frameworks for transition metal catalysis, enabling highly enantioselective transformations.
• Organocatalyst Development: Serves as a core structure for designing novel organocatalysts used in green and sustainable chemistry applications.
• Chemical Biology Probe Synthesis: Employed in creating molecular probes and tools to study enzyme function and biological pathways.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of novel polymers with specific mechanical or chiral properties.
• Agrochemical Synthesis: Utilized in the research and development of advanced, stereochemically-defined agrochemicals.

Basic Information

Product Name	(1R,4R)-2,5-Diazabicyclo[2.2.2]Octane-2-Carboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	1240782-81-3
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	(1R,4R)-2,5-Diazabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester; tert-Butyl (1R,4R)-2,5-diazabicyclo[2.2.2]octane-2-carboxylate; (1R,4R)-2-(tert-Butoxycarbonyl)-2,5-diazabicyclo[2.2.2]octane; (1R,4R)-2-Boc-2,5-diazabicyclo[2.2.2]octane; Boc-DABCO derivative (chiral); (1R,4R)-2,5-Diaza-bicyclo[2.2.2]octane-2-carboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our (1R,4R)-2,5-Diazabicyclo[2.2.2]Octane-2-Carboxylic Acid 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.