Description

3-Azabicyclo[3.2.1]Octane-8-Carboxylic Acid Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique bridged bicyclic structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules with targeted biological activity. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a constrained scaffold to explore structure-activity relationships (SAR) and improve the pharmacokinetic properties of lead compounds.
• API Synthesis: Integral building block in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Employed in chiral synthesis due to its rigid, three-dimensional structure, which can impart stereochemical control.
• Chemical Biology Probes: Serves as a core structure for developing molecular probes to study biological pathways and target validation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.

Basic Information

Product Name	3-Azabicyclo[3.2.1]Octane-8-Carboxylic Acid Hydrochloride
CAS No.	1240526-59-3
Molecular Formula	C8H13NO2 • HCl
Molecular Weight	191.65 g/mol (Free base: 155.19 g/mol)
Synonyms	8-Carboxy-3-azabicyclo[3.2.1]octane hydrochloride; 3-Azabicyclo[3.2.1]octane-8-carboxylic acid, hydrochloride; 8-Carboxy-3-azanorbornane hydrochloride; endo-3-Azabicyclo[3.2.1]octane-8-carboxylic acid HCl; Tropane-3-carboxylic acid hydrochloride (related scaffold); 3-Aza-8-carboxynorbornane hydrochloride; 8-Carboxy-8-azabicyclo[3.2.1]octane hydrochloride (common misnomer); Bicyclo[3.2.1]octane-8-carboxylic acid, 3-aza-, hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Azabicyclo[3.2.1]Octane-8-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Production can be aligned with cGMP guidelines for pharmaceutical applications upon request, ensuring reliable supply for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.