Description

tert-Butyl 5,5-Dichloro-6-Oxo-2-Azaspiro[3.3]heptane-2-carboxylate is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors and other small-molecule therapeutics. It is primarily sought by research institutions and pharmaceutical companies engaged in drug discovery and process chemistry for its role as a key building block in complex organic syntheses.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel protease inhibitors and other targeted therapeutic agents.
• Drug Discovery Research: Used as a versatile building block in medicinal chemistry for constructing complex spirocyclic molecular architectures.
• Process Chemistry & Scale-Up: Serves as a key starting material for the development and optimization of commercial-scale API manufacturing routes.
• Chemical Biology Probes: Utilized in the development of specialized probes for studying enzyme function and biological pathways.
• Custom Synthesis: Employed by fine chemical suppliers for the preparation of bespoke compounds and libraries for client research programs.

Basic Information

Product Name	tert-Butyl 5,5-Dichloro-6-Oxo-2-Azaspiro[3.3]heptane-2-carboxylate
CAS No.	1239320-10-5
Molecular Formula	C11H15Cl2NO3
Molecular Weight	280.15 g/mol
Synonyms	2-Azaspiro[3.3]heptane-2-carboxylic acid, 5,5-dichloro-6-oxo-, 1,1-dimethylethyl ester; tert-Butyl 5,5-dichloro-6-oxo-2-azaspiro[3.3]heptane-2-carboxylate; 2-(tert-Butoxycarbonyl)-5,5-dichloro-2-azaspiro[3.3]heptan-6-one; 5,5-Dichloro-6-oxo-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester; Boc-5,5-dichloro-2-azaspiro[3.3]heptan-6-one
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 5,5-Dichloro-6-Oxo-2-Azaspiro[3.3]heptane-2-carboxylate adheres to stringent quality management systems, ensuring batch-to-batch consistency for critical research and development applications. The material is characterized by advanced analytical techniques including HPLC, GC, NMR, and MS to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.