Description

2-(Aminomethyl)-6-Azaspiro[3.4]Octane-6-Carboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, protected amino acid derivative and a key spirocyclic building block in modern organic synthesis. This compound is critical for research and development teams requiring advanced intermediates with precise stereochemistry and functional group compatibility. It is primarily utilized by pharmaceutical and biotechnology companies for the discovery and development of novel therapeutic agents, particularly in medicinal chemistry programs targeting complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those incorporating spirocyclic and constrained ring systems.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve drug-like properties.
• Peptidomimetic Synthesis: Serves as a constrained, non-natural amino acid analog for creating peptide mimics with enhanced metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the development of tool compounds and molecular probes for studying biological pathways and target engagement.
• Library Synthesis for Drug Discovery: A valuable scaffold for generating diverse compound libraries in high-throughput screening (HTS) initiatives.
• Process Chemistry Development: Used in route scouting and scale-up studies for the efficient and cost-effective manufacturing of candidate drugs.

Basic Information

Product Name	2-(Aminomethyl)-6-Azaspiro[3.4]Octane-6-Carboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	1239320-01-4
Molecular Formula	C13H24N2O2
Molecular Weight	240.34 g/mol
Synonyms	tert-Butyl 2-(aminomethyl)-6-azaspiro[3.4]octane-6-carboxylate; 6-(tert-Butoxycarbonyl)-2-(aminomethyl)-6-azaspiro[3.4]octane; 2-(Aminomethyl)-6-azaspiro[3.4]octane-6-carboxylic acid tert-butyl ester; Boc-6-Azaspiro[3.4]octane-2-methylamine; N-Boc-2-(Aminomethyl)-6-azaspiro[3.4]octane; 1,1-Dimethylethyl 2-(aminomethyl)-6-azaspiro[3.4]octane-6-carboxylate; Spirocyclic Boc-protected amine
EINECS	Contact for details

Quality Control

Our 2-(Aminomethyl)-6-Azaspiro[3.4]Octane-6-Carboxylic Acid 1,1-Dimethylethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.