Description

6-Azaspiro[3.4]Octane-6-Carboxylic Acid, 2-Amino-, 1,1-Dimethylethyl Ester is a high-value, protected amino acid derivative featuring a unique spirocyclic scaffold, making it a critical building block in advanced organic synthesis. Its primary value lies in its role as a key chiral intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially within therapeutic areas targeting the central nervous system and metabolic diseases.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon in the synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• Peptidomimetics & Bioactive Molecule Design: Used to incorporate constrained, spirocyclic motifs into peptide backbones to enhance metabolic stability and receptor selectivity.
• Chemical Biology & Proteomics: Employed as a building block for creating specialized molecular probes and activity-based protein profiling (ABPP) reagents.
• Asymmetric Catalysis & Ligand Development: Acts as a precursor for synthesizing novel chiral ligands and organocatalysts.
• Agrochemical Research: Utilized in the discovery and development of new crop protection agents with novel modes of action.
• Academic & Industrial R&D: A valuable reagent for methodological development in synthetic organic chemistry and material science.

Basic Information

Product Name	6-Azaspiro[3.4]Octane-6-Carboxylic Acid, 2-Amino-, 1,1-Dimethylethyl Ester
CAS No.	1239319-94-8
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	tert-Butyl 2-amino-6-azaspiro[3.4]octane-6-carboxylate; 2-Amino-6-azaspiro[3.4]octane-6-carboxylic acid tert-butyl ester; 6-(tert-Butoxycarbonyl)-6-azaspiro[3.4]octan-2-amine; Boc-6-azaspiro[3.4]octan-2-amine; 2-Amino-6-Boc-6-azaspiro[3.4]octane; 6-Azaspiro[3.4]octane-6-carboxylic acid, 2-amino-, 1,1-dimethylethyl ester; (2-Amino-6-azaspiro[3.4]octan-6-yl)(tert-butoxy)methanone
EINECS	Contact for details

Quality Control

Our production of 6-Azaspiro[3.4]Octane-6-Carboxylic Acid, 2-Amino-, 1,1-Dimethylethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.