Description

tert-Butyl 3-(Quinolin-2-yl)azetidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidine-quinoline hybrid scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in oncology and CNS drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degraders.
• Kinase Inhibitor Synthesis: The quinoline moiety makes it valuable for constructing potential kinase inhibitors.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological processes and target validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke APIs and intermediates.

Basic Information

Product Name	tert-Butyl 3-(Quinolin-2-yl)azetidine-1-carboxylate
CAS No.	1236861-63-4
Molecular Formula	C17H20N2O2
Molecular Weight	284.36 g/mol
Synonyms	1-Boc-3-(quinolin-2-yl)azetidine; tert-Butyl 3-(2-quinolyl)azetidine-1-carboxylate; 3-(Quinolin-2-yl)azetidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-(quinolin-2-yl)azetidine; Azetidine-1-carboxylic acid, 3-(2-quinolinyl)-, 1,1-dimethylethyl ester; 2-(1-Boc-3-azetidinyl)quinoline; BOC-3-(2-Quinolyl)azetidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Quinolin-2-yl)azetidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.