Description

n-(4-Chlorophenyl)-5-Hydroxy-1-Oxo-2,3-Dihydropyrrolo[1,2-A]Quinazoline-3A(1H)-Carboxamide is a high-purity, advanced pharmaceutical intermediate with a complex fused heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in high-throughput screening campaigns.
• API Development: Integral in the process development and scale-up of new chemical entities (NCEs) due to its specific quinazoline-pyrrolo fused ring system.
• Biochemical Research: May be employed as a tool compound or inhibitor in enzymatic and receptor-binding assays to study biological pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	n-(4-Chlorophenyl)-5-Hydroxy-1-Oxo-2,3-Dihydropyrrolo[1,2-A]Quinazoline-3A(1H)-Carboxamide
CAS No.	1236267-23-4
Molecular Formula	C19H14ClN3O3
Molecular Weight	367.79 g/mol
Synonyms	5-Hydroxy-1-oxo-N-(4-chlorophenyl)-2,3-dihydro-1H-pyrrolo[1,2-a]quinazoline-3a-carboxamide; 1H-Pyrrolo[1,2-a]quinazoline-3a(1H)-carboxamide, 2,3-dihydro-5-hydroxy-1-oxo-N-(4-chlorophenyl)-; n-(4-chlorophenyl)-5-hydroxy-1-oxo-2,3-dihydro-1H-pyrrolo[1,2-a]quinazoline-3a-carboxamide; CAS 1236267-23-4
EINECS	Contact for details

Quality Control

Our n-(4-Chlorophenyl)-5-Hydroxy-1-Oxo-2,3-Dihydropyrrolo[1,2-A]Quinazoline-3A(1H)-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and pre-clinical use. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Single Maximum Impurity	≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.