Description

tert-Butyl Azetidine-3-Carboxylate Acetate is a high-value, protected azetidine carboxylic acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the efficient construction of complex nitrogen-containing heterocycles and constrained peptidomimetics, which are essential for modulating biological activity. This compound is particularly sought after by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, where its rigid, four-membered ring structure offers unique conformational control.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small molecule drug candidates targeting a range of therapeutic areas.
• Peptidomimetic Scaffold: Used to introduce the constrained azetidine ring into peptide backbones, enhancing metabolic stability and bioavailability in drug discovery programs.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides, fungicides, and insecticides that require specific stereochemistry.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Chemical Biology Probe Synthesis: Utilized to create tool compounds for studying enzyme function and protein-protein interactions.
• Material Science Research: Investigated as a monomer or building block for specialty polymers with unique thermal or mechanical properties.

Basic Information

Product Name	tert-Butyl Azetidine-3-Carboxylate Acetate
CAS No.	1236144-52-7
Molecular Formula	C10H17NO4
Molecular Weight	215.25 g/mol
Synonyms	1-Boc-3-Azetidinecarboxylic Acid Acetate; tert-Butyl 3-Carboxyazetidine-1-carboxylate Acetate; 1-(tert-Butoxycarbonyl)azetidine-3-carboxylic Acid Acetate; Azetidine-3-carboxylic Acid, 1-(1,1-Dimethylethoxy)carbonyl-, Acetate; 3-((tert-Butoxycarbonyl)amino)azetidine-3-carboxylate Acetate; 1-Boc-Azetidine-3-Carboxylic Acid Acetate Salt; Boc-Aze(3)-OH Acetate
EINECS	Contact for details

Quality Control

Our tert-Butyl Azetidine-3-Carboxylate Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.