Description

4-Bromo-3-Nitro-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazole is a high-value, multi-functional heterocyclic building block used in advanced organic synthesis. This compound matters for its role as a key precursor in the development of novel pharmaceuticals and agrochemicals, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical scaffold in the synthesis of potential drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, leveraging its reactive bromo and nitro substituents.
• Material Science Research: Acts as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Cross-Coupling Reactions: The bromo substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form biaryl structures.
• Nucleophilic Substitution: The nitro group can be reduced to an amine, providing a handle for further derivatization into amides, sulfonamides, or ureas.

Basic Information

Product Name	4-Bromo-3-Nitro-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazole
CAS No.	1235407-33-6
Molecular Formula	C8H10BrN3O3
Molecular Weight	276.09 g/mol
Synonyms	4-Bromo-3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole; 1-(Oxan-2-yl)-4-bromo-3-nitro-1H-pyrazole; 4-Bromo-3-nitro-1-(tetrahydropyran-2-yl)pyrazole; 4-Bromo-3-nitro-1-(THP)-1H-pyrazole; 4-Bromo-3-nitro-1-(2-tetrahydropyranyl)-1H-pyrazole; 1H-Pyrazole, 4-bromo-3-nitro-1-(tetrahydro-2H-pyran-2-yl)-; THP-protected 4-bromo-3-nitropyrazole
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Nitro-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.