Description

(S)-tert-Butyl 3-(1H-Benzo[D]Imidazol-2-Yl)Piperidine-1-Carboxylate is a high-purity chiral building block and advanced pharmaceutical intermediate of significant importance in modern organic synthesis. Its value lies in its defined stereochemistry and functionalized piperidine-benzimidazole core, which is a privileged scaffold in medicinal chemistry. This compound is essential for research and development chemists in the pharmaceutical and biotechnology industries, particularly for the synthesis of targeted therapeutics and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates targeting various therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold for constructing compound libraries in structure-activity relationship (SAR) studies and high-throughput screening.
• API Development: Serves as a critical building block in the development and scale-up of Active Pharmaceutical Ingredients (APIs), especially those containing benzimidazole and piperidine motifs.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes to study biological pathways and enzyme functions.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective synthesis to introduce complex molecular architectures.
• Contract Research & Manufacturing (CRMO): Supplied to organizations specializing in custom synthesis and process development for client projects.

Basic Information

Product Name	(S)-tert-Butyl 3-(1H-Benzo[D]Imidazol-2-Yl)Piperidine-1-Carboxylate
CAS No.	1234709-86-4
Molecular Formula	C17H23N3O2
Molecular Weight	301.39 g/mol
Synonyms	1-Boc-3-(1H-benzimidazol-2-yl)-(S)-piperidine; (S)-1-tert-Butoxycarbonyl-3-(1H-benzimidazol-2-yl)piperidine; (S)-1-Boc-3-(1H-benzoimidazol-2-yl)piperidine; (S)-3-(1H-Benzoimidazol-2-yl)-1-piperidinecarboxylic acid tert-butyl ester; (S)-tert-Butyl 3-(1H-benzoimidazol-2-yl)piperidine-1-carboxylate; (S)-N-Boc-3-(1H-benzimidazol-2-yl)piperidine; (S)-1-N-Boc-3-(2-benzimidazolyl)piperidine
EINECS	Contact for details

Quality Control

Our production of (S)-tert-Butyl 3-(1H-Benzo[D]Imidazol-2-Yl)Piperidine-1-Carboxylate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.