Description

(R)-3-(Methylsulfonyl)Piperidine Hydrochloride CAS NO 1234576-83-0 is a high-purity chiral piperidine derivative, a critical building block in modern pharmaceutical synthesis. Its value lies in providing a stereochemically defined, functionalized scaffold essential for creating novel active pharmaceutical ingredients (APIs) with targeted biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) therapeutics, enzyme inhibitors, and other small molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for neurological and psychiatric disorders.
• Asymmetric Synthesis: Used as a precursor or catalyst ligand in stereoselective chemical reactions to create enantiomerically pure compounds.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs to modify pharmacokinetic properties.
• Protease & Enzyme Inhibitor Development: The methylsulfonyl and basic piperidine motifs make it valuable for designing molecules that interact with specific enzyme active sites.
• Chemical Biology Probes: Utilized in the synthesis of tool compounds for investigating biological pathways and target validation.
• Agrochemical Research: Potential intermediate in the development of advanced, chiral crop protection agents.

Basic Information

Product Name	(R)-3-(Methylsulfonyl)Piperidine Hydrochloride
CAS No.	1234576-83-0
Molecular Formula	C7H15NO2S • HCl
Molecular Weight	213.72 g/mol (Free base: 177.26 g/mol)
Synonyms	(R)-3-Methanesulfonylpiperidine hydrochloride; (R)-Piperidine-3-sulfonic acid methyl ester hydrochloride; (3R)-3-(Methylsulfonyl)piperidine HCl; (R)-3-(Methylsulfonyl)piperidine HCl salt; (R)-3-Methylsulfonylpiperidine hydrochloride; (R)-3-(Methanesulphonyl)piperidine hydrochloride; (R)-3-(Methylsulfonyl)piperidinium chloride
EINECS	Contact for details

Quality Control

Our (R)-3-(Methylsulfonyl)Piperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.