Description

3-(Chloromethyl)-2-Cyclopropyl-4-(4'-Fluorophenyl) Quinoline is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), enabling the development of next-generation therapeutics. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key synthon for the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Serves as a precursor in the synthesis of novel pesticides and herbicides, leveraging its quinoline core for biological activity.
• Material Science: Used in the development of specialty chemicals and functional materials, including organic light-emitting diodes (OLEDs) and liquid crystals.
• Chemical Biology: Acts as a versatile scaffold for creating molecular probes and inhibitors in biochemical and pharmacological studies.
• Process Chemistry: Employed in route scouting and optimization for scalable API manufacturing processes.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	3-(Chloromethyl)-2-Cyclopropyl-4-(4'-Fluorophenyl) Quinoline
CAS No.	1234331-56-6
Molecular Formula	C19H15ClFN
Molecular Weight	311.78 g/mol
Synonyms	2-Cyclopropyl-4-(4-fluorophenyl)-3-(chloromethyl)quinoline; 4-(4-Fluorophenyl)-2-cyclopropyl-3-(chloromethyl)quinoline; 3-Chloromethyl-2-cyclopropyl-4-(4-fluorophenyl)quinoline; Quinoline, 3-(chloromethyl)-2-cyclopropyl-4-(4-fluorophenyl)-; 1234331-56-6; 2-Cyclopropyl-4-(4'-fluorophenyl)-3-quinolinylmethyl chloride
EINECS	Contact for details

Quality Control

Our 3-(Chloromethyl)-2-Cyclopropyl-4-(4'-Fluorophenyl) Quinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.