Description

cis-1-tert-Butyl 3-Ethyl 4-Aminopyrrolidine-1,3-Dicarboxylate Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel drug candidates, including protease inhibitors and other small-molecule therapeutics.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the production of sophisticated APIs, especially in antiviral and oncology research pipelines.
• Protease Inhibitor Development: Used in the research and scale-up manufacturing of protease inhibitor drugs, leveraging its chiral pyrrolidine core.
• Medicinal Chemistry & Drug Discovery: Employed in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic entities.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic & Industrial Research: Utilized in chemical biology and organic synthesis research for developing novel heterocyclic compounds.

Basic Information

Product Name	cis-1-tert-Butyl 3-Ethyl 4-Aminopyrrolidine-1,3-Dicarboxylate Hydrochloride
CAS No.	1233501-65-9
Molecular Formula	C13H25N2O4•HCl
Molecular Weight	308.81 g/mol (Free base: 273.35 g/mol)
Synonyms	1-tert-Butyl 3-ethyl (3R,4S)-4-aminopyrrolidine-1,3-dicarboxylate hydrochloride; (3R,4S)-1-(tert-Butoxycarbonyl)-3-(ethoxycarbonyl)-4-aminopyrrolidine hydrochloride; 4-Aminopyrrolidine-1,3-dicarboxylic acid 1-tert-butyl 3-ethyl ester hydrochloride (cis); cis-4-Amino-1-Boc-3-(ethoxycarbonyl)pyrrolidine HCl; BOC-D-4-Amino-pyrrolidine-3-carboxylic acid ethyl ester hydrochloride; (3R,4S)-4-Amino-1-N-Boc-3-N-ethoxycarbonylpyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of cis-1-tert-Butyl 3-Ethyl 4-Aminopyrrolidine-1,3-Dicarboxylate Hydrochloride is manufactured and controlled under a strict quality management system. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure compliance with exacting purity and stereochemical specifications required for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request, supporting regulatory submissions and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.