Description

2-(((9H-Fluoren-9-Yl)Methoxy)Carbonyl)-6-Methoxy-1,2,3,4-Tetrahydroisoquinoline-4-Carboxylic Acid CAS NO 1233025-96-1 is a sophisticated, high-purity Fmoc-protected amino acid derivative, specifically designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over peptide chain assembly, particularly in the development of complex therapeutic peptides and peptidomimetics. It is an essential building block for pharmaceutical R&D, biotechnology, and academic research focused on novel drug discovery and chemical biology.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the sequential addition of amino acids using Fmoc chemistry protocols.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Peptidomimetic Design: Serves as a constrained scaffold for creating non-natural peptide analogs with enhanced metabolic stability and bioavailability.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Bioconjugation and Probe Development: Facilitates the site-specific incorporation of the tetrahydroisoquinoline moiety into peptides for labeling or functional studies.
• Academic and Institutional Research: A valuable reagent for studying peptide structure-activity relationships (SAR) and synthetic methodology development.

Basic Information

Product Name	2-(((9H-Fluoren-9-Yl)Methoxy)Carbonyl)-6-Methoxy-1,2,3,4-Tetrahydroisoquinoline-4-Carboxylic Acid
CAS No.	1233025-96-1
Molecular Formula	C26H23NO6
Molecular Weight	445.46 g/mol
Synonyms	Fmoc-6-methoxy-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid; Fmoc-6-MeO-Tic-OH; 2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid; 6-Methoxy-Fmoc-Tic-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-6-methoxy-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid; Fmoc-6-methoxy-Tic; 4-Carboxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline, N-Fmoc derivative
EINECS	Contact for details

Quality Control

Our production of 2-(((9H-Fluoren-9-Yl)Methoxy)Carbonyl)-6-Methoxy-1,2,3,4-Tetrahydroisoquinoline-4-Carboxylic Acid adheres to stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis where applicable. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.